تفاعل #1243390

معادلة التفاعل

sodium carbonate

2',6'-dinitro-2-chloroacetanilide

chloromethyl methyl ether

methylene chloride

→

2-Chloro-2',6'-Dinitro-N-(Methoxymethyl)Acetanilide

المردود 80.0%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added 3.0 g
2. 2
   workup.STIRRINGstirring
3. 3
   أخرىseparation
4. 4
   workup.WAITto stand overnight
5. 5
   أخرىm.p. 105.5°-108° C. was obtained in 80% yield

الإجراء التجريبي

To a 500 ml. stirred flask was added 3.0 g. (0.012 moles) of 2',6'-dinitro-2-chloroacetanilide, 2.5 ml. of chloromethyl methyl ether, 1.0 g. of phase transfer catalyst and 150 ml. of methylene chloride. Thereafter, 75 ml. saturated sodium carbonate solution was added in one portion and stirring continued for 50 minutes. At the end of this period, water was added to aid separation and the aqueous/organic mixture was allowed to stand overnight. The product, 2-chloro-2',6'-dinitro-N-(methoxymethyl)acetanilide, 2.9 g. m.p. 105.5°-108° C. was obtained in 80% yield.

المصدر