تفاعل #1224

معادلة التفاعل

4-iodo-2-trichloroacetylpyrrole

methanol

sodium methoxide

→

methyl 4-iodo-2-pyrrolecarboxylate

المذيبات

water

ethyl ether

ظروف التفاعل

المعالجة

1. 1
   أخرىthe reaction medium evaporated to dryness
2. 2
   أخرىthe residue obtained
3. 3
   أخرىThe organic phase was decanted off
4. 4
   تجفيفdried over magnesium sulfate
5. 5
   أخرىevaporated
6. 6
   أخرىThe residue obtained
7. 7
   أخرىwas triturated in heptane
8. 8
   ترشيحfiltered
9. 9
   أخرى4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered

الإجراء التجريبي

8.2 g (24 mmol) of 4-iodo-2-trichloroacetylpyrrole and 100 ml of methanol were introduced into a round-bottomed flask and 2 g (36 mmol) of sodium methoxide were added. The mixture was stirred at room temperature for four hours, the reaction medium evaporated to dryness, and the residue obtained taken up in water and ethyl ether. The organic phase was decanted off, dried over magnesium sulfate and evaporated. The residue obtained was triturated in heptane and filtered; 4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered.

المصدر