تفاعل #12069

معادلة التفاعل

4-vinyl benzylchloride

dimethylsulfoxide

potassium cyanide

→

4-vinylbenzylcyanide

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted several times with ethyl acetate
2. 2
   غسيلThe combined organic layers were washed with brine
3. 3
   تركيزconcentrated under vacuum
4. 4
   أخرىThe crude red oil was purified by column chromatography on silica gel using 7/93 ethyl acetate/hexane

الإجراء التجريبي

A mixture of 22.2 g 4-vinyl benzylchloride (0.131 mol), 60 mL dimethylsulfoxide, and 12.8 g potassium cyanide (0.196 mol) was stirred at room temperature for 17 hours. The mixture was poured into 500 mL water and extracted several times with ethyl acetate. The combined organic layers were washed with brine and concentrated under vacuum. The crude red oil was purified by column chromatography on silica gel using 7/93 ethyl acetate/hexane to give 4-vinylbenzylcyanide, a yellow oil (18.03 g, 96%).

المصدر