تفاعل #1206

معادلة التفاعل

ethanolamine

1-tetradecyloxy-3-methyl-2-butene oxide

→

title compound

المردود 58.0%

3-(2-hydroxyethylamino)-4-tetradecyloxy-2-methyl-2-butanol

المردود 58.0%

المذيبات

ethanol

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىA 100-ml two-necked flask equipped with a stirrer and a dropping funnel
2. 2
   درجة الحرارةWhile heating
3. 3
   درجة الحرارةAfter heating
4. 4
   workup.STIRRINGstirring the mixture further for 16 hours
5. 5
   أخرىthe resultant reaction mixture
6. 6
   تركيزwas concentrated under reduced pressure
7. 7
   أخرىthe resultant residue was purified by column chromatography on silica gel

الإجراء التجريبي

A 100-ml two-necked flask equipped with a stirrer and a dropping funnel was charged with 15.3 g (16.7 mmol) of ethanolamine and 5.0 g of ethanol. While heating and stirring the mixture at 80° C. in a nitrogen atmosphere, an ethanol solution of 5.00 g (16.7 mmol) of 1-tetradecyloxy-3-methyl-2-butene oxide was added dropwise over 3 hours. After heating and stirring the mixture further for 16 hours, the resultant reaction mixture was concentrated under reduced pressure, and the resultant residue was purified by column chromatography on silica gel, thereby obtaining 3.47 g (yield: 58%) of the title compound (IIc-4).

المصدر