تفاعل #11971

معادلة التفاعل

compound

(2S)-2-(4-(N-Boc-N-2-picolylamino)methylnaphthalene-1-carbonyl)amino-5-((8S)-5,6,7,8-tetrahydroquinolin-8-yl)aminovaleric acid 1-naphthylmethylamide

hydrochloric acid dioxane

→

hydrochloride

title compound

(2S)-2-(4-(N-2-picolylaminomethyl)naphthalene-1-carbonyl)amino-5-((8S)-5,6,7,8-tetrahydroquinolin-8-yl)aminovaleric acid 1-naphthylmethylamide

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter the reaction for 3.5 hours
2. 2
   تركيزthe reaction solution was concentrated
3. 3
   أخرىThe residue obtained
4. 4
   أخرىwas purified by silica gel column chromatography (0.5 g, chloroform/methanol/water=7/3/0.5)
5. 5
   workup.ADDITIONtreated with hydrochloric acid

الإجراء التجريبي

The compound obtained in Example 90-2 (14.2 mg) was dissolved in methanol (0.3 ml), and 4 mol/l hydrochloric acid/dioxane solution (0.3 ml) was added to the solution. After the reaction for 3.5 hours, the reaction solution was concentrated. The residue obtained was purified by silica gel column chromatography (0.5 g, chloroform/methanol/water=7/3/0.5) and treated with hydrochloric acid to obtain hydrochloride of the title compound (8.1 mg) as a white solid.

المصدر