تفاعل #11952

معادلة التفاعل

compound

Nα-(4-(8-quinolylaminomethyl)benzoyl)-Nδ-Boc-L-ornithine

hydrochloric acid dioxane

→

title compound

(S)-2-(4-(8-quinolylaminomethyl)benzoylamino)-5-(2-picolylamino)valeric acid

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter the reaction for 1 hour
2. 2
   تركيزthe reaction solution was concentrated
3. 3
   أخرىdried under reduced pressure
4. 4
   workup.DISSOLUTIONThe resulting residue was dissolved in methanol (2 ml)
5. 5
   workup.ADDITIONpyridine-2-aldehyde (18 μl) and triethylamine (27 μl) were added
6. 6
   تركيزthe reaction solution was concentrated
7. 7
   أخرىdried under reduced pressure
8. 8
   workup.DISSOLUTIONThe residue was again dissolved in methanol (2 ml)
9. 9
   workup.ADDITIONsodium borohydride (22 mg) was added
10. 10
    أخرىAfter the reaction for 1 hour
11. 11
    تركيزthe reaction solution was concentrated
12. 12
    أخرىThe residue was purified by silica gel column chromatography (4 g, chloroform/methanol/water=7/3/0.5)

الإجراء التجريبي

The compound obtained in Example 16-3 (122.6 mg) was dissolved in methanol (1.2 ml) and 4 mol/l hydrochloric acid/dioxane solution (1.2 ml) was added. After the reaction for 1 hour, the reaction solution was concentrated and dried under reduced pressure. The resulting residue was dissolved in methanol (2 ml), and pyridine-2-aldehyde (18 μl) and triethylamine (27 μl) were added. After 15 hours, the reaction solution was concentrated and dried under reduced pressure. The residue was again dissolved in methanol (2 ml) and sodium borohydride (22 mg) was added. After the reaction for 1 hour, the reaction solution was concentrated. The residue was purified by silica gel column chromatography (4 g, chloroform/methanol/water=7/3/0.5) to obtain the title compound (114.0 mg) as an orange solid.

المصدر