تفاعل #11948

معادلة التفاعل

trifluoroacetic acid

thioanisole

m-cresol

compound

Nα-(5-(N-Boc-N-2-picolylaminomethyl)thiophene-2-carbonyl)-Nδ-Cbz-L-ornithine

→

title compound

المردود 53.3%

Nα-(5-(N-2-picolylaminomethyl)thiophene-2-carbonyl)-L-ornithine

المردود 53.3%

ظروف التفاعل

المعالجة

1. 1
   تركيزthe reaction solution was concentrated
2. 2
   workup.ADDITIONMethanol was added to the residue
3. 3
   غسيلthe mixture was washed with hexane
4. 4
   تركيزThe methanol layer was concentrated
5. 5
   أخرىthe residue was crude-purified by silica gel column chromatography (3 g, chloroform/methanol/water=7/3/0.5)

الإجراء التجريبي

A mixed solution of trifluoroacetic acid (1.4 ml), thioanisole (0.36 ml), and m-cresol (0.32 ml) was added to the compound obtained in Example 14-3 (56.2 mg). After 1.5 hours, the reaction solution was concentrated. Methanol was added to the residue and the mixture was washed with hexane. The methanol layer was concentrated and the residue was crude-purified by silica gel column chromatography (3 g, chloroform/methanol/water=7/3/0.5) to obtain the title compound (18.2 mg) as colorless syrup.

المصدر