تفاعل #1194

معادلة التفاعل

ethanolamine

10-(2-ethylhexyloxy)decyl glycidyl ether

→

title compound

المردود 68.4%

1-(2-hydroxyethylamino)-3-[10-(2-ethylhexyloxy)decyloxy]-2-propanol

المردود 68.4%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىA 200-ml two-necked flask equipped with a stirrer
2. 2
   درجة الحرارةreflux tube
3. 3
   درجة الحرارةWhile heating
4. 4
   workup.STIRRINGstirred further for 18 hours
5. 5
   تركيزit was concentrated under reduced pressure
6. 6
   أخرىthe resultant residue was purified by column chromatography on silica gel

الإجراء التجريبي

A 200-ml two-necked flask equipped with a stirrer, reflux tube and dropping funnel was charged with 32.7 g (0.54 mol) of ethanolamine and 10.1 g of ethanol. While heating and stirring the mixture at 80° C., 1.76 g (5.14 mmol) of 10-(2-ethylhexyloxy)decyl glycidyl ether were added dropwise over 2 hours. After the resultant mixture was heated and stirred further for 18 hours, it was concentrated under reduced pressure, and the resultant residue was purified by column chromatography on silica gel, thereby obtaining 1.42 g (yield: 68%) of the title compound (Ia-14).

المصدر