تفاعل #1190

معادلة التفاعل

ethanolamine

12-hydroxyoctadecyl glycidyl ether

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title compound

المردود 77.0%

1-(2-hydroxyethylamino)-3-(12-hydroxyoctadecyloxy)-2-propanol

المردود 77.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىA 200-ml flask equipped with a stirrer
2. 2
   درجة الحرارةreflux condenser
3. 3
   تركيزit was concentrated under reduced pressure
4. 4
   أخرىpurified by column chromatography on silica gel

الإجراء التجريبي

A 200-ml flask equipped with a stirrer, reflux condenser and dropping funnel was charged with 35.0 g (0.57 mol) of ethanolamine and 35 g of ethanol, and the mixture was heated to 80° C. with stirring in a nitrogen atmosphere. To this mixture, 13.0 g (38 mmol) of 12-hydroxyoctadecyl glycidyl ether were added dropwise over 3 hours. After the resultant mixture was stirred further for 3 hours, it was concentrated under reduced pressure and purified by column chromatography on silica gel, thereby obtaining 11.7 g (yield: 77%) of the title compound (Ia-1).

المصدر