تفاعل #11826

معادلة التفاعل

4-aminoethylphenol

triethylamine

vinylacetyl chloride

→

4-vinylacetamidoethyl phenol

المردود 80.0%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   أخرىA 1000 mL 3-neck, round bottom flask connected with a reflux condenser and a drying tube
2. 2
   درجة الحرارةThe contents are chilled with an ice bath
3. 3
   أخرىThe ice bath is then removed
4. 4
   ترشيحThe mixture is then filtered
5. 5
   أخرىcondensed
6. 6
   أخرىto give
7. 7
   أخرىa final purified product with a yield of at least 80 percent

الإجراء التجريبي

A 1000 mL 3-neck, round bottom flask connected with a reflux condenser and a drying tube, is charged with 250 mL of methylene chloride, 5.48 grams (0.04 mole) 4-aminoethylphenol and 4.04 grams (0.04 mole) triethylamine. The contents are chilled with an ice bath. Through a dropping funnel, 4.18 grams (0.04 mole) of vinylacetyl chloride is added into the flask over a period of 30 minutes. The ice bath is then removed and the contents are continuously stirred overnight. The mixture is then filtered and then condensed using a rotavapor. HPLC analysis indicates only one major product. The product is then passed through silica gel chromatography to give a final purified product with a yield of at least 80 percent. The product is identified by NMR and Mass Spectroscopy.

المصدر