تفاعل #1180087

معادلة التفاعل

trimethylsilyl cyanide

1-(bis-prop-2-ynyloxy-methyl)-4-chloro-benzene

hydrochloric acid

→

(4-chloro-phenyl)-prop-2-ynyloxy-acetonitrile

المردود 63.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe organic phase is separated
2. 2
   تجفيفdried (magnesium sulfate)
3. 3
   أخرىevaporated

الإجراء التجريبي

Under an atmosphere of nitrogen, trimethylsilyl cyanide (3.1 g) is added to bismuth (III)bromide (0.22 g) and 1-(bis-prop-2-ynyloxy-methyl)-4-chloro-benzene (6.7 g) in dichloromethane (50 ml) at room temperature. The reaction mixture is stirred for 48 hours at room temperature and then poured into 0.5 M hydrochloric acid (50 ml). The organic phase is separated, dried (magnesium sulfate) and evaporated. Crude (4-chloro-phenyl)-prop-2-ynyloxy-acetonitrile (3.7 g) is obtained as oil.

المصدر