تفاعل #11796

معادلة التفاعل

sodium triacetoxyborohydride

5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzaldehyde

sarcosine methyl ester hydrochloride salt

→

[(5-Chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzyl)-methyl-amino]-acetic acid methyl ester

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter 15 hours the solvent was removed
2. 2
   غسيلAfter washing with pH 7 phosphate buffer (0.05 M) and saturated aqueous sodium chloride the organic layer
3. 3
   تجفيفwas dried over magnesium sulfate
4. 4
   ترشيحAfter filtration and concentration the title compound
5. 5
   أخرىwas isolated by chromatography on silica gel (0.051 g)

الإجراء التجريبي

To a solution of 5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzaldehyde (0.10 g, 0.24 mmol) in methanol (2.5 ml) was added sarcosine methyl ester hydrochloride salt (0.10 g, 0.72 mmol) followed by sodium triacetoxyborohydride (0.155 g, 0.73 mmol). After 15 hours the solvent was removed and the resultant solid taken up in methylene chloride. After washing with pH 7 phosphate buffer (0.05 M) and saturated aqueous sodium chloride the organic layer was dried over magnesium sulfate. After filtration and concentration the title compound was isolated by chromatography on silica gel (0.051 g).

المصدر