تفاعل #1178456

معادلة التفاعل

ethyl [4-(3-oxomorpholin-4-yl)phenyl]acetate

→

4-(3-oxomorpholin-4-yl)phenylacetic acid

المذيبات

sodium hydroxide

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture is evaporated
2. 2
   workup.DISSOLUTIONthe residue is dissolved in water
3. 3
   استخلاصThe mixture is extracted with ethyl acetate
4. 4
   تجفيفthe organic phase is dried over sodium sulfate
5. 5
   أخرىevaporated

الإجراء التجريبي

20.2 g (76.8 mmol) of ethyl [4-(3-oxomorpholin-4-yl)phenyl]acetate are dissolved in a solution of 3.37 g of sodium hydroxide in 40 ml of ethanol, and the reaction solution is stirred at room temperature for 18 hours. The reaction mixture is evaporated, and the residue is dissolved in water and acidified to a pH of 3 using 1N hydrochloric acid. The mixture is extracted with ethyl acetate, and the organic phase is dried over sodium sulfate and evaporated, giving 4-(3-oxomorpholin-4-yl)phenylacetic acid as a yellowish solid; ESI 236.

المصدر