تفاعل #1178424

معادلة التفاعل

DCC

Boc-Aib-OH

MeNHOMe.HCl

i-Pr2NEt

→

[1-(methoxy-methyl-carbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester

المردود 80.0%

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture was filtered
2. 2
   أخرىto remove
3. 3
   أخرىprecipitated N,N′-dicyclohexylurea
4. 4
   أخرىthe filtrate was evaporated under reduced pressure
5. 5
   workup.DISSOLUTIONThe residue was dissolved in ethyl acetate (200 mL)
6. 6
   غسيلwashed with 10% aqueous citric acid (3×200 mL), 10% aqueous NaHCO3 (3×200 mL) and saturated aqueous sodium chloride (3×200 mL)
7. 7
   تجفيفdried over MgSO4
8. 8
   أخرىRemoval of the solvent
9. 9
   أخرىyielded the crude product which
10. 10
    أخرىwas purified by column chromatography (hexane/ethyl acetate 60:40)

الإجراء التجريبي

To a stirred mixture of Boc-Aib-OH (5 g, 24.61 mmol, 1 eq), MeNHOMe.HCl (2.88 g, 29.53 mmol, 1.2 eq), DMAP (3.61 g, 29.53 mmol, 1.2 eq), i-Pr2NEt (5.02 mL, 29.53 mmol, 1.2 eq) and CH2Cl2 (100 mL) was added DCC (6.09 g, 29.53 mmol, 1.2 eq). The mixture was stirred at room temperature for 5 days. The mixture was filtered to remove precipitated N,N′-dicyclohexylurea and the filtrate was evaporated under reduced pressure. The residue was dissolved in ethyl acetate (200 mL), washed with 10% aqueous citric acid (3×200 mL), 10% aqueous NaHCO3 (3×200 mL) and saturated aqueous sodium chloride (3×200 mL), and dried over MgSO4. Removal of the solvent yielded the crude product which was purified by column chromatography (hexane/ethyl acetate 60:40) to afford [1-(methoxy-methyl-carbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester (4.85 g, 80%) as a white solid. 1H NMR (200 MHz, CDCl3) δ (ppm): 1.43 (s, 6H), 1.58 (s, 9H), 3.22 (s, 3H), 3.69 (s, 3H), 6.95 (bs, 1H). MS (ESI, +ve ion): m/z 247.2 (M+1)+.

المصدر