تفاعل #1178413

معادلة التفاعل

2,2-dimethoxypropane

p-toluenesulfonic acid monohydrate

→

(2,2-dimethyl-[1,3]dioxan-5-yl)-methanol

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwere added
2. 2
   أخرىAs much solvent as possible was removed in vacuo
3. 3
   workup.DISTILLATIONthe remainder was purified by distillation under vacuum

الإجراء التجريبي

Triol 3-1 (1 eq.) was dissolved in DMF at a concentration of approximately 0.5 M and 2,2-dimethoxypropane (1.16 eq.) and p-toluenesulfonic acid monohydrate (0.03 eq.) were added. The solution was stirred for one or more days, and was quenched with TEA (0.5 eq.). As much solvent as possible was removed in vacuo and the remainder was purified by distillation under vacuum.

المصدر