تفاعل #11770

معادلة التفاعل

2-(5-chloro-3-nitro-pyridin-2-yloxy)-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone

hydrogen

→

title compound

المردود 86.3%

2-(3-Amino-5-chloro-pyridin-2-yloxy)-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone

المردود 86.3%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction was filtered through celite
2. 2
   تركيزconcentrated in vacuo
3. 3
   أخرىchromatographed on silica gel

الإجراء التجريبي

To a solution of 2-(5-chloro-3-nitro-pyridin-2-yloxy)-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone (0.96 g, 2.3 mmol) in ethanol (25 mL) was added platinum dioxide on carbon (0.90 mg, 5% on carbon). The reaction was subject to 35 psi hydrogen gas for 20 minutes. The reaction was filtered through celite, concentrated in vacuo and chromatographed on silica gel to give the title compound (0.78 g).

المصدر