تفاعل #11765

معادلة التفاعل

(5-chloro-2-methoxy-phenyl)-methanesulfonamide

boron tribromide

→

title compound

المردود 86.8%

(5-Chloro-2-hydroxy-phenyl)-methanesulfonamide

المردود 86.8%

المذيبات

dichloroethane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction was quenched with water, saturated with sodium chloride
2. 2
   استخلاصextracted with ethyl acetate
3. 3
   تجفيفThe organic layer was dried over sodium sulfate
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated

الإجراء التجريبي

To a suspension of (5-chloro-2-methoxy-phenyl)-methanesulfonamide (0.03 g, 0.13 mmol) in dichloroethane (1.5 mL) was added boron tribromide solution (1M in dichloromethane, 0.26 mL, 0.26 mmol). The reaction was stirred for one hour at ambient temperature. The reaction was quenched with water, saturated with sodium chloride and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, filtered and concentrated to give the title compound (0.025 g).

المصدر