تفاعل #11764

معادلة التفاعل

4-chloro-2-chloromethyl-1-methoxybenzene

cesium carbonate

thioacetic acid

→

title compound

المردود 96.0%

Thioacetic acid S-(5-chloro-2-methoxy-benzyl)ester

المردود 96.0%

المذيبات

ethyl acetate

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with water, 5% aqueous sodium hydrogen carbonate, and brine
2. 2
   أخرىThe organic layer was separated
3. 3
   تجفيفdried over sodium sulfate
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated in vacuo

الإجراء التجريبي

To a solution of cesium carbonate (0.55 g, 1.70 mmol) in dimethylformamide (13 mL) was added thioacetic acid (0.24 g, 3.14 mmol) followed by addition of 4-chloro-2-chloromethyl-1-methoxybenzene (0.50 g, 2.62 mmol) in one portion. The reaction was stirred in the dark at ambient temperature overnight. The reaction was diluted with ethyl acetate, washed with water, 5% aqueous sodium hydrogen carbonate, and brine. The organic layer was separated, dried over sodium sulfate, filtered and concentrated in vacuo. Chromatography on silica gel gave the title compound (0.58 g).

المصدر