تفاعل #1174652

معادلة التفاعل

2-Amino-4-methylbenzothiazole

methoxyacetyl chloride

→

title compound

2-(methoxyacetylamino)-4-methylbenzothiazole

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONthe solvent is distilled off
2. 2
   workup.ADDITIONThe resulting oil is solidified with addition of water
3. 3
   ترشيحThe obtained solids are filtered off
4. 4
   غسيلwashed with water
5. 5
   تجفيفwith diethyl ether, dried
6. 6
   أخرىrecrystallized from ethanol

الإجراء التجريبي

2-Amino-4-methylbenzothiazole (4.9 g) is dissolved in pyridine (100 ml) and thereto is added dropwise methoxyacetyl chloride (3.0 ml) at room temperature. After the mixture is stirred at room temperature for 2 hours, the solvent is distilled off. The resulting oil is solidified with addition of water. The obtained solids are filtered off and washed with water, then with diethyl ether, dried and recrystallized from ethanol to give the title compound (5.2 g) having the following physical properties.

المصدر