تفاعل #1172664

معادلة التفاعل

1,2-Epoxy-2,3-dihydro-1-H indene

indene

pyrrolidine

→

trans-2,3-dihydro-2-hydroxy-1-(pyrrolidin-1-yl)-1H-indene

ظروف التفاعل

المعالجة

1. 1
   أخرىevaporated
2. 2
   أخرىto remove the excess pyrrolidine under reduced pressure
3. 3
   workup.DISTILLATIONThe residue was distilled under vacuum

الإجراء التجريبي

1,2-Epoxy-2,3-dihydro-1-H indene, prepared from indene (34.2 g) according to the procedure of M. Imuta and H. Ziffer, J. Org. Chem., 44, 1351 (1979), was treated immediately with pyrrolidine (50 ml). The exothermic reaction mixture was set aside for 15 minutes and then evaporated to remove the excess pyrrolidine under reduced pressure. The residue was distilled under vacuum to yield trans-2,3-dihydro-2-hydroxy-1-(pyrrolidin-1-yl)-1H-indene (10.2 g), b.p. 148°-150°/0.25 torr.

المصدر