تفاعل #1172511

معادلة التفاعل

potassium

4-hydroxyacetophenone

methyl 2-chloropropanoate

→

methyl 2-(4-acetylphenoxy)propanoate

المردود 80.4%

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction is filtered
2. 2
   أخرىto remove KCl
3. 3
   تركيزthe filtrate is concentrated under reduced pressure
4. 4
   أخرىto remove DMF
5. 5
   workup.DISSOLUTIONThe product is dissolved in ethyl acetate (300 mL)
6. 6
   استخلاصextracted with 2N NaOH (2×100 mL) and water (100 mL)
7. 7
   أخرىThe organic phase is dried
8. 8
   تركيزconcentrated

الإجراء التجريبي

To a solution of the potassium salt of 4-hydroxyacetophenone (25.0 g, 0.14 mol) in dimethylformamide (DMF) (100 mL) is added methyl 2-chloropropanoate (24.5 g, 0.20 mol) over 30 minutes and stirred at 85-90° C. for 3 hours under nitrogen. The reaction is filtered to remove KCl and the filtrate is concentrated under reduced pressure to remove DMF and the product analyzed by GLC. The product is dissolved in ethyl acetate (300 mL) and extracted with 2N NaOH (2×100 mL) and water (100 mL). The organic phase is dried and concentrated to give pure methyl 2-(4-acetylphenoxy)propanoate (25 g) (yield 64%).

المصدر