تفاعل #11722

معادلة التفاعل

2-chloro-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone

4-chloro-2-nitro-phenol

potassium carbonate

potassium iodide

→

title compound

المردود 94.8%

2-(4-Chloro-2-nitro-phenoxy)-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone

المردود 94.8%

المذيبات

2-butanone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction was refluxed overnight
2. 2
   درجة الحرارةcooled
3. 3
   تركيزconcentrated in vacuo

الإجراء التجريبي

To a solution of 2-chloro-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone (0.40 g, 1.4 mmol) in 2-butanone (14 mL) was added 4-chloro-2-nitro-phenol (0.25 g, 1.4 mmol), potassium carbonate (0.39 g, 2.8 mmol) and potassium iodide (233 mg, 1.4 mmol). The reaction was refluxed overnight, cooled and concentrated in vacuo. Chromatography on silica gel gave the title compound (0.56 g).

المصدر