تفاعل #1171

معادلة التفاعل

4-Piperidinecarboxamide

benzyl bromide

→

N-benzyl-4-piperidinecarboxamide

المردود 35.0%

المذيبات

EtOAc

DMSO

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with 1N aq. HCl, 5N aq. NaOH
2. 2
   تجفيفdried over MgSO4
3. 3
   تركيزconcentrated

الإجراء التجريبي

4-Piperidinecarboxamide (10.2 g, 78.0 mmol) in DMSO (10 mL) was treated with benzyl bromide (20.0 mL, 168 mmol). The mixture was diluted with EtOAc and washed with 1N aq. HCl, 5N aq. NaOH, dried over MgSO4, and concentrated to give 5.90 g (35%) of N-benzyl-4-piperidinecarboxamide. [1H]-NMR(CDCl3) consistent with structure.

المصدر