تفاعل #1169

معادلة التفاعل

sulfuryl chloride

benzyl phenyl ether

→

4-benzyloxybenzenesulfonyl chloride

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooled
2. 2
   استخلاصextracted with brine and methylene chloride
3. 3
   تجفيفdried over MgSO4

الإجراء التجريبي

A 1.12 portion of anhydrous DMF is cooled to 0° C. and treated dropwise with 2.06 g of sulfuryl chloride. The resulting suspension is stirred for 30 min., then treated with 1.50 g of benzyl phenyl ether. The mixture is heated at 90° C. for 3 h, then cooled, extracted with brine and methylene chloride, and dried over MgSO4. Chormotography on silica gel (i-PrOH/hexanes) yields 4-benzyloxybenzenesulfonyl chloride.

المصدر