تفاعل #1166460

معادلة التفاعل

hydrochloric acid

triethylamine

trans-4-n-propylcyclohexanecarbonyl chloride

water

→

ethyl trans-4-n-propylcyclohexylcarboxylate

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with isopropyl ether
2. 2
   غسيلThe organic layer was repeatedly washed with water until the aqueous layer
3. 3
   تجفيفby drying with magnesium sulfate, distilling-off of the solvent and purification by silica gel column chromatography

الإجراء التجريبي

A small amount of triethylamine was added to 10 g (53.6 mmol) of trans-4-n-propylcyclohexanecarbonyl chloride dissolved in 30 ml of ethanol, followed by 10 hours of stirring at room temperature. The reaction mixture was poured into 100 ml of iced water, acidified with 6N-hydrochloric acid and extracted with isopropyl ether. The organic layer was repeatedly washed with water until the aqueous layer became neutral, followed by drying with magnesium sulfate, distilling-off of the solvent and purification by silica gel column chromatography to obtain 9.9 g of ethyl trans-4-n-propylcyclohexylcarboxylate.

المصدر