تفاعل #1162471

معادلة التفاعل

3-oximino-2,4-hexanedione

d,l-norvaline

5-acetyl-4-methyl-2-propylimidazole

→

4-methyl-5-propinoyl-2-propylimidazole

المردود 48.0%

المذيبات

n-butanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was refluxed 6.25 h
2. 2
   درجة الحرارةcooled
3. 3
   تركيزconcentrated in vacuo
4. 4
   ترشيحsuction filtered
5. 5
   غسيلthe filtrate washed with 10% aqueous sodium hydroxide (4×100 ml)
6. 6
   أخرىRemoval of the solvent in vacuo

الإجراء التجريبي

To 92.4 g (0.646 moles) of 3-oximino-2,4-hexanedione dissolved in 807 ml of n-butanol was added 90.75 g (0.775 moles) of d,l-norvaline. The mixture was refluxed 6.25 h, then cooled and concentrated in vacuo. The residue was taken up in ethyl acetate (500 ml), suction filtered and the filtrate washed with 10% aqueous sodium hydroxide (4×100 ml). Removal of the solvent in vacuo gave 0.29 moles (48% yield based on recovered amino acid) of 4-methyl-5-propinoyl-2-propylimidazole and 5-acetyl-4-methyl-2-propylimidazole (87:13 respectively).

المصدر