تفاعل #1159638

معادلة التفاعل

toluene-4-sulfonic acid 8-methyl-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-2-ylmethyl ester

trans-4-(5-fluoro-1H-indol-3-yl)-cyclohexylamine

→

product

المردود 18.0%

(trans)-N-[4-(5-fluoro-1H-indol-3-yl)cyclohexyl]-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}amine

المردود 18.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىThis compound was prepared in a manner similar to Example 1

الإجراء التجريبي

This compound was prepared in a manner similar to Example 1, using toluene-4-sulfonic acid 8-methyl-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-2-ylmethyl ester (0.5 g, 1.29 mmol) and trans-4-(5-fluoro-1H-indol-3-yl)-cyclohexylamine (0.4 g, 1.72 mmol) to give 0.09 g (18%) product as the fumarate salt: MS (ESI) m/z 446 [M+H]+.

المصدر