تفاعل #1159631

معادلة التفاعل

3-(5-fluoro-1-methyl-1H-indol-3-yl)-cyclopentanone

benzylamine

→

desired product

المردود 101.6%

N-Benzyl-3-(5-fluoro-1-methyl-1H-indol-3yl)-cyclopentylamine

المردود 101.6%

ظروف التفاعل

الإجراء التجريبي

This compound was prepared in the same manner as for Intermediate 17, using 3-(5-fluoro-1-methyl-1H-indol-3-yl)-cyclopentanone (1.25 g, 5.19 mmol) and benzylamine (0.66 g, 6.2 mmol) to afford 1.7 g of the desired product as a mixture of cis and trans isomers. Flash chromatography on silica gel (3% 2 M NH3 in methanol/ethyl acetate) afforded 0.4 g (23%) of the cis isomer and 0.45 g (27%) of the trans isomer.

المصدر