تفاعل #11561

معادلة التفاعل

Methyl iodide

1-[2-(1-adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea

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titled compound

المردود 96.0%

4-[3-[3-[2-(1-Adamantyl)ethyl]-3-pentylureido]propyl]-1-methylpyridinium iodide

المردود 96.0%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated under reduced pressure from the reaction mixture
2. 2
   ترشيحthe precipitated crystals were filtered off with ethyl acetate

الإجراء التجريبي

Methyl iodide (90 μl, 1.5 mmol) was added to a solution of 1-[2-(1-adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea (Compound No. 1-1) (0.30 g, 0.73 mmol) in acetone (1.5 ml) at room temperature, and the mixture was stirred overnight. The solvent was evaporated under reduced pressure from the reaction mixture, and the precipitated crystals were filtered off with ethyl acetate to give 389 mg (96%) of the titled compound.

المصدر