تفاعل #1152664

معادلة التفاعل

hydrochloric acid

1,7,7-trimethyl-2-bicyclo(2,2,1)heptylidene-(6-morpholino-3-pyridazinyl)-hydrazine

→

1,7,7-trimethyl-2-bicyclo(2,2,1)heptylidene-(6-chloro-3-pyridazinyl)-hydrazine

المردود 65.0%

المذيبات

chloroform

chloroform

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis heated at 60°
2. 2
   أخرىis separated from the reaction mixture every hour
3. 3
   أخرىThe camphor recovered can
4. 4
   أخرىcondensed with 6-chloro-3-pyridazinylhydrazine

الإجراء التجريبي

A mixture of 32.9 g (0.1 moles) of 1,7,7-trimethyl-2-bicyclo(2,2,1)heptylidene-(6-morpholino-3-pyridazinyl)-hydrazine (prepared by the process of Example 8, Step b), 660 ml of chloroform and 660 ml of concentrated hydrochloric acid is heated at 60° while stirring under a nitrogen atmosphere for 6 hours in such a way that the chloroform layer is separated from the reaction mixture every hour and replaced by fresh solvent (660 ml). The camphor recovered can be condensed with 6-chloro-3-pyridazinylhydrazine to give pure 1,7,7-trimethyl-2-bicyclo(2,2,1)heptylidene-(6-chloro-3-pyridazinyl)-hydrazine in 65-72% yield.

المصدر