تفاعل #11523

معادلة التفاعل

water

4-(2-Chloroethyl)morpholine hydrochloride

1-benzothiophene-4-ol

potassium carbonate

dimethylformamide

→

product

2-[(1-Benzothien-4-yloxy)ethyl]morpholine

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooling
2. 2
   استخلاصextracted twice with ethyl acetate
3. 3
   غسيلThe combined solvent phase was washed twice with brine
4. 4
   تجفيفdried (magnesium sulphate)
5. 5
   أخرىevaporated

الإجراء التجريبي

4-(2-Chloroethyl)morpholine hydrochloride (0.74 g), 1-benzothiophene-4-ol (0.5 g) and potassium carbonate (1.1 g) in dimethylformamide (15 ml) were heated and stirred at 80° C. for 6 h. After cooling, the mixture was poured into water and extracted twice with ethyl acetate. The combined solvent phase was washed twice with brine, dried (magnesium sulphate) and evaporated to give the product (0.7 g).

المصدر