تفاعل #1152005

معادلة التفاعل

Potassium carbonate

1-(2-hydroxyethyl)piperazine

2-bromo-N-(2,6-diisopropyl-4-hydroxyphenyl)acetamide

→

2-[4-(2-hydroxyethyl)piperazin-1-yl]-N-(2,6-diisopropyl-4-hydroxyphenyl)acetamide

المردود 69.0%

المذيبات

acetonitrile

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with chloroform
2. 2
   غسيلThe organic layer was washed with water
3. 3
   تجفيفa saturated sodium chloride solution successively and dried oven anhydrous sodium sulfate
4. 4
   أخرىthe solvent was evaporated
5. 5
   أخرىThe crude crystals were recrystallized from acetone-hexane

الإجراء التجريبي

Potassium carbonate (1.52 g, 11 mmol) was added to a solution of 1-(2-hydroxyethyl)piperazine (1.43 g, 11 mmol) and 2-bromo-N-(2,6-diisopropyl-4-hydroxyphenyl)acetamide in acetonitrile (50 ml) and the mixture was stirred at room temperature for 12 hours. The reaction solution was diluted with water and extracted with chloroform. The organic layer was washed with water and a saturated sodium chloride solution successively and dried oven anhydrous sodium sulfate and the solvent was evaporated therefrom. The crude crystals were recrystallized from acetone-hexane to provide 2.5 g (yield 69%) of 2-[4-(2-hydroxyethyl)piperazin-1-yl]-N-(2,6-diisopropyl-4-hydroxyphenyl)acetamide as colorless needles.

المصدر