تفاعل #1151486

معادلة التفاعل

5-(3-Dimethylaminoprop-2-enoyl)-1,2-dimethylimidazole

2-(3-Chloroanilino)-4-(2-methylimidazol-5-yl)pyrimidin

phenylguanidine hydrogen carbonate

→

title compound

المردود 26.3%

2-Anilino-4-(1,2-dimethylimidazol-5-yl)pyrimidine

المردود 26.3%

ظروف التفاعل

الإجراء التجريبي

5-(3-Dimethylaminoprop-2-enoyl)-1,2-dimethylimidazole (Method 1; 314 mg, 1.62 mmol) and phenylguanidine hydrogen carbonate (321 mg, 1.62 mmol) were treated as described in Example 1 to give the title compound 113 mg, (26%) as a solid. NMR: 2.37 (s, 3H), 3.93 (s, 3H), 6.95 (t, 1H), 7.08 (d, 1H), 7.28 (t, 2H), 7.59 (s, 1H), 7.69 (d, 2H), 8.35 (d, 1H), 9.43 (s, 1H); m/z: 266.

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