تفاعل #11500

معادلة التفاعل

water

4-hydroxybenzoic acid

potassium carbonate

2-propyloxyethyl chloride

→

title compound

المردود 105.6%

4-(2-Propyloxyethoxy)benzoic acid

المردود 105.6%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGstirred at 80° C. for 8 hours
2. 2
   استخلاصthe mixture was extracted with ethyl acetate
3. 3
   غسيلThe organic layer was washed with water
4. 4
   تجفيفa saturated aqueous solution of sodium chloride, successively, dried
5. 5
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

To a solution of 4-hydroxybenzoic acid (3.04 g) and anhydrous potassium carbonate (5.52 g) in N,N-dimethylformamide (20 ml) was added 2-propyloxyethyl chloride (2.94 g), and the mixture was stirred at room temperature overnight, and then stirred at 80° C. for 8 hours. To a reaction solution was added water, and then the mixture was extracted with ethyl acetate. The organic layer was washed with water and a saturated aqueous solution of sodium chloride, successively, dried and concentrated under reduced pressure to give the title compound (5.21 g; crude).

المصدر