تفاعل #1149061

معادلة التفاعل

diisopropylamine

triethylamine

6-bromo-2-naphthoyl chloride

→

title compound

6-bromo-N,N-diisopropyl-2-naphthamide

المذيبات

THF

THF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooling
2. 2
   أخرىA half amount of the solvent was evaporated under reduced pressure
3. 3
   workup.ADDITIONthe residue was diluted with ethyl acetate
4. 4
   غسيلwashed successively with water, 1N aqueous sodium hydroxide solution, water and saturated brine
5. 5
   تجفيفdried over magnesium sulfate
6. 6
   أخرىThe solvent was evaporated
7. 7
   غسيلthe obtained solid was washed with isopropyl ether

الإجراء التجريبي

To a solution (800 mL) of diisopropylamine (112 mL) and triethylamine (112 mL) in THF was added dropwise a solution (400 mL) of 6-bromo-2-naphthoyl chloride in THF under ice-cooling. The mixture was stirred at room temperature for 1 hr. A half amount of the solvent was evaporated under reduced pressure, and the residue was diluted with ethyl acetate, washed successively with water, 1N aqueous sodium hydroxide solution, water and saturated brine and dried over magnesium sulfate. The solvent was evaporated and the obtained solid was washed with isopropyl ether to give the title compound (117 g) as colorless flakes.

المصدر