تفاعل #1147741

ord-34a8f05fdaef43cab4d576414d98435f

معادلة التفاعل

CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Cl)nc(I)nc32)[C@H](OC(=O)c2ccccc2)[C@@H]1OC(=O)c1ccccc1
(2R,3R,4S,5S)-4-(benzoyloxy)-2-(6-chloro-2-iodo-9H-purin-9-yl)-5-[(ethylamino)carbonyl]-tetrahydro-3-furanyl benzoate
NC1CCCCC1
cyclohexylamine
→
CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCCCC4)nc(I)nc32)[C@H](OC(=O)c2ccccc2)[C@@H]1OC(=O)c1ccccc1
title compound
CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCCCC4)nc(I)nc32)[C@H](OC(=O)c2ccccc2)[C@@H]1OC(=O)c1ccccc1
(2R,3R,4S,5S)-4-(Benzoyloxy)-2-[6-(cyclohexylamino)-2-iodo-9H-purin-9-yl]-5-[(ethylamino)carbonyl]tetrahydro-3-furanyl benzoate

المتفاعلات

CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Cl)nc(I)nc32)[C@H](OC(=O)c2ccccc2)[C@@H]1OC(=O)c1ccccc1
(2R,3R,4S,5S)-4-(benzoyloxy)-2-(6-chloro-2-iodo-9H-purin-9-yl)-5-[(ethylamino)carbonyl]-tetrahydro-3-furanyl benzoate
NC1CCCCC1
cyclohexylamine

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىas Preparation 20

الإجراء التجريبي

Prepared from ((2R,3R,4S,5S)-4-(benzoyloxy)-2-(6-chloro-2-iodo-9H-purin-9-yl)-5-[(ethylamino)carbonyl]-tetrahydro-3-furanyl benzoate (Preparation 19) and cyclohexylamine by the same method as Preparation 20. The title compound was obtained as a yellow foam.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US06525032B2uspto-grants-2003_02