تفاعل #1144435

معادلة التفاعل

5-ethyluracil

potassium carbonate

→

1-butyl-5-ethyluracil

المردود 69.0%

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture was concentrated under reduced pressure
2. 2
   تركيزthe organic layer was concentrated under reduced pressure
3. 3
   غسيلeluted with 30% ethyl acetate/hexane

الإجراء التجريبي

To a solution of 5.6 g (40 mmol) of 5-ethyluracil in 60 ml of dimethylformamide, 5.5 g (40 mmol) of potassium carbonate and 2.3 ml (20 mmol) of n-iodobutane were added and stirred for 2 hours at 120° C. The reaction mixture was concentrated under reduced pressure and distributed between dichloromethane and aqueous solution of ammonium chloride, and the organic layer was concentrated under reduced pressure. The residue was adsorbed on a silica gel column and eluted with 30% ethyl acetate/hexane to obtain 2.7 g of 1-butyl-5-ethyluracil (Yield: 69%).

المصدر