تفاعل #1142049

معادلة التفاعل

water

3-bromo-2,6-dichloropyridine

sodium methoxide

→

title compound

المردود 93.2%

3-bromo-6-chloro-2-methoxypyridine

المردود 93.2%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىthe organic was evaporated
2. 2
   ترشيحThe resulting suspension was filtered
3. 3
   غسيلthe pad was washed with water for several times
4. 4
   أخرىThe pad was dried

الإجراء التجريبي

To a solution of 3-bromo-2,6-dichloropyridine (3.00 g, 13.2 mmol) in acetonitrile (20 mL) was added sodium methoxide (methanol solution, 4.83 mol/L, 3.0 mL) dropwise at 0° C. The mixture was stirred at room temperature over night. To the mixture was added 30 mL of water, and the organic was evaporated. The resulting suspension was filtered, and the pad was washed with water for several times. The pad was dried under reduce pressure to give title compound (2.74 g, 93.2%) as white solid.

المصدر