تفاعل #1138940

معادلة التفاعل

water

8-bromo-6-chloroimidazo[1,2-b]pyridazine

phenylmethanol

NaH

→

8-(benzyloxy)-6-chloroimidazo[1,2-b]pyridazine

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThe resulting mixture is stirred at RT for an additional 2 h
2. 2
   استخلاصThe mixture is extracted with ethyl acetate (2×100 mL)
3. 3
   غسيلThe combined organic layers are washed with brine
4. 4
   تجفيفdried over Na2SO4
5. 5
   ترشيحfiltered
6. 6
   تركيزThe filtrate is concentrated in vacuo

الإجراء التجريبي

To a stirred solution of phenylmethanol (3.35 g, 31 mmol, 1.2 eq) in THF (80 mL), NaH (60% dispersion in mineral oil, 1.34 g, 33.5 mmol, 1.3 eq) is added in portions. The resulting mixture is stirred at RT for 30 min and then 8-bromo-6-chloroimidazo[1,2-b]pyridazine (D-3) (6 g, 25.8 mmol, 1.0 eq) is added. The resulting mixture is stirred at RT for an additional 2 h and then poured into water (30 mL). The mixture is extracted with ethyl acetate (2×100 mL). The combined organic layers are washed with brine, dried over Na2SO4 and filtered. The filtrate is concentrated in vacuo to afford the product, 8-(benzyloxy)-6-chloroimidazo[1,2-b]pyridazine (D-4).

المصدر