تفاعل #1136643

معادلة التفاعل

3-(4,4-dimethylpentyl)-2′-fluoro-5′-methoxy-[1,1′-biphenyl]-4-ol

triphenylphosphine

ethyl 3-cyclopropyl-3-(3-(hydroxymethyl)phenyl)propanoate

diethyl azodicarboxylate

→

title compound

المردود 78.5%

ethyl 3-cyclopropyl-3-(3-(((3-(4,4-dimethylpentyl)-2′-fluoro-5′-methoxy-[1,1′-biphenyl]-4-yl)oxy)methyl)phenyl)propanoate

المردود 78.5%

المذيبات

THF

toluene

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture was concentrated under reduced pressure
2. 2
   أخرىthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

الإجراء التجريبي

To a solution of 3-(4,4-dimethylpentyl)-2′-fluoro-5′-methoxy-[1,1′-biphenyl]-4-ol (280 mg) in THF (5.0 mL) were added triphenylphosphine (348 mg), ethyl 3-cyclopropyl-3-(3-(hydroxymethyl)phenyl)propanoate (330 mg) and a 40% solution of diethyl azodicarboxylate in toluene (600 μL), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (380 mg) as a colorless oil.

المصدر