تفاعل #11363

معادلة التفاعل

compound

2-(5-Nitro-2propoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

→

2-(5-Amino-2-propoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

المذيبات

tetrahydrofuran ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe product is purified by silica gel chromalography

الإجراء التجريبي

Analogously to the procedure of example 42A, 5.13 g (12.96 mmol) of the compound from example 43A are hydrogenated in tetrahydrofuran/ethanol (1:1) using 1.11 g of 10% Pd/C. The product is purified by silica gel chromalography using toluene and ethyl acetate as solvent gradient.

المصدر