تفاعل #1135841

معادلة التفاعل

methyl 8-(2-(cyclopropylamino)phenylamino)-8-oxooctanoate

acetic acid

→

methyl 7-(1-cyclopropyl-1H-benzo[d]imidazol-2-yl)heptanoate

المردود 67.7%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated
2. 2
   أخرىThe residue was purified by biotage column chromatography

الإجراء التجريبي

To a solution of methyl 8-(2-(cyclopropylamino)phenylamino)-8-oxooctanoate (390 mg) in toluene was added a drop of acetic acid. The reaction was heated to 110° C. overnight and concentrated. The residue was purified by biotage column chromatography to give methyl 7-(1-cyclopropyl-1H-benzo[d]imidazol-2-yl)heptanoate (249 mg)

المصدر