تفاعل #1135812

معادلة التفاعل

2-methyl-3-nitrophenol

iodoethane

potassium carbonate

→

1-ethoxy-2-methyl-3-nitrobenzene

المردود 100.7%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwith heating
2. 2
   درجة الحرارةunder reflux for ten hours
3. 3
   ترشيحfiltered
4. 4
   تركيزthe resulting filtrates were concentrated
5. 5
   استخلاصThe resulting mixtures were extracted with ethyl acetate
6. 6
   غسيلthe organic layers were washed with water and saturated saline
7. 7
   تجفيفwere dried over anhydrous magnesium sulfate
8. 8
   تركيزwere then concentrated under reduced pressure

الإجراء التجريبي

A mixture of 2-methyl-3-nitrophenol 33.5 g, iodoethane 41 g and potassium carbonate 90 g in acetone 400 mL was stirred with heating under reflux for ten hours. The mixtures were cooled to room temperature and filtered and the resulting filtrates were concentrated. The resulting mixtures were extracted with ethyl acetate and the organic layers were washed with water and saturated saline, and were dried over anhydrous magnesium sulfate and were then concentrated under reduced pressure. The resulting residues were subjected to a silica gel column chromatography to give 1-ethoxy-2-methyl-3-nitrobenzene 39.9 g.

المصدر