تفاعل #11358

معادلة التفاعل

5-benzyloxy-2-ethoxybenizonitrile

5-Benzyloxy-2-ethoxybenzonitrile

→

Ethoxy-5-hydroxybenzonitrile

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture is filtered through kieselguhr
2. 2
   أخرىevaporated
3. 3
   أخرىthe crystalline residue is dried under reduced pressure

الإجراء التجريبي

40.02 g of 5-benzyloxy-2-ethoxybenizonitrile (158 mmol) (example 32A) and 5% Pd/C (4.0 g) are initially charged in 1 l of methanol. The mixture is then hydrogenated under an atmosphere of hydrogen (1 atm) for about 4 h. The mixture is filtered through kieselguhr and evaporated and the crystalline residue is dried under reduced pressure.

المصدر