تفاعل #1135797

معادلة التفاعل

methyl chloroformate

tetrahydrofuran

1-chloro-2-methyl-3-aminobenzene

→

1-chloro-2-methyl-3-methoxycarbonylaminobenzene

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىTo the reaction mixtures
2. 2
   استخلاصthe resulting mixtures were extracted with ethyl acetate
3. 3
   غسيلThe organic layers were washed with aqueous saturated sodium bicarbonate solution
4. 4
   تجفيفwere dried over anhydrous sodium sulfate
5. 5
   تركيزThe mixtures were concentrated under reduced pressure

الإجراء التجريبي

Under cooling, to a mixture of methyl chloroformate 30 mL and tetrahydrofuran 50 mL was added dropwise 1-chloro-2-methyl-3-aminobenzene 5.00 g and the mixtures were stirred at 25° C. for a half hour. To the reaction mixtures was added water and the resulting mixtures were extracted with ethyl acetate. The organic layers were washed with aqueous saturated sodium bicarbonate solution and were dried over anhydrous sodium sulfate. The mixtures were concentrated under reduced pressure to give 1-chloro-2-methyl-3-methoxycarbonylaminobenzene 5.80 g.

المصدر