تفاعل #1132923

معادلة التفاعل

2-chloro-6-methylpyrazine

1-methylpiperazine

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product

المردود 45.3%

2-Methyl-6-(4-methylpiperazin-1-yl)pyrazine

المردود 45.3%

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe resulting mixture was heated
2. 2
   درجة الحرارةat reflux overnight
3. 3
   أخرىthe solvent was evaporated
4. 4
   workup.ADDITIONThe residue was mixed with saturated aqueous NaHCO3 (100 mL)
5. 5
   استخلاصextracted with CH2Cl2 (100 mL×3)
6. 6
   تجفيفThe combined organic layers were dried over anhydrous Na2SO4
7. 7
   تركيزconcentrated in vacuo
8. 8
   أخرىThe residue was further purified by flash column chromatography on silica gel with 4% MeOH in CH2Cl2

الإجراء التجريبي

A 250 mL round bottom flask was charged with 2-chloro-6-methylpyrazine (4.0 g, 0.031 mol), 1-methylpiperazine (12.4 g, 0.125 mol) and EtOH (100 mL). The resulting mixture was heated at reflux overnight. Work-up: the solvent was evaporated. The residue was mixed with saturated aqueous NaHCO3 (100 mL) and then extracted with CH2Cl2 (100 mL×3). The combined organic layers were dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was further purified by flash column chromatography on silica gel with 4% MeOH in CH2Cl2, to afford 2.7 g (45%) of the product as a white solid. MS m/z: 193 (M+H+).

المصدر