تفاعل #1130124

معادلة التفاعل

dimethyl 2,2′-thiodiacetate

sodium (meta)periodate

→

dimethyl 2,2′-sulfinyldiacetate

المردود 91.3%

المذيبات

brine

water

ظروف التفاعل

المعالجة

1. 1
   أخرىthe resulting reaction mixture
2. 2
   استخلاصextracted with CHCl3 (5×)
3. 3
   تجفيفdried with anhydrous sodium sulfate
4. 4
   أخرىThe solution was decanted
5. 5
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

To the mixture of dimethyl 2,2′-thiodiacetate (4.54 g, 25.5 mmol, 1 eq) in water (50 mL) at 0° C. was added sodium (meta)periodate (5.786 g, 1.05 eq) and the resulting reaction mixture was stirred overnight. The mixture was then diluted with brine and extracted with CHCl3 (5×). All organics were combined and dried with anhydrous sodium sulfate. The solution was decanted, concentrated under reduced pressure, and the clear oily residue was subject to column chromatography (EtOAc-Hex 1:5 to 1:1) giving dimethyl 2,2′-sulfinyldiacetate as a clear oil (4.522 g).

المصدر