تفاعل #1126445

معادلة التفاعل

N-(4-Hydroxy-3-oxo-2,3-dihydro-1H-inden-5-yl)acetamide

pyridinium p-toluenesulfonate

→

title compound

المردود 85.0%

2-Methyl-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-one

المردود 85.0%

المذيبات

xylene

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated under reduced pressure
2. 2
   أخرىthe residue was purified by silica gel column chromatography (ethyl acetate/hexane=10/90→100/0)

الإجراء التجريبي

N-(4-Hydroxy-3-oxo-2,3-dihydro-1H-inden-5-yl)acetamide (469 mg, 2.29 mmol) and pyridinium p-toluenesulfonate (115 mg, 0.457 mmol) were heated under reflux in xylene (23 mL) for 2.5 hr. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (ethyl acetate/hexane=10/90→100/0) to give the title compound (363 mg, yield 85%).

المصدر