تفاعل #1122667

معادلة التفاعل

3-nitro[1,5]naphthyridin-4-amine

3-nitroquinolin-4-amine

quinoline-3,4-diamine

[1,5]naphthyridine-3,4-diamine

→

1H-imidazo[4,5-c]quinoline

1H-imidazo[4,5-c][1,5]naphthyridine

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الإجراء التجريبي

In steps (2) and (3) of Reaction Scheme II, a 3-nitroquinolin-4-amine or 3-nitro[1,5]naphthyridin-4-amine of Formula XXVI is first reduced to a quinoline-3,4-diamine or [1,5]naphthyridine-3,4-diamine of Formula XXVII, which is then treated with a halogen-substituted carboxylic acid equivalent to provide a 1H-imidazo[4,5-c]quinoline or 1H-imidazo[4,5-c][1,5]naphthyridine of Formula XXVIII. Steps (2) and (3) of Reaction Scheme II can be carried out according to the methods described in steps (3) and (4) of Reaction Scheme I.

المصدر