تفاعل #1121781

معادلة التفاعل

231

2-Benzyl-8-(4-methoxyphenylthio)-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one

acetyl chloride

→

25a

المردود 66.0%

2-Benzyl-8-(4-methoxyphenylthio)-6-phenylimidazo[1,2-a]pyrazin-3-yl acetate

المردود 66.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   غسيلThen the solution was washed with water
2. 2
   تجفيفthe organic layer was dried over Na2SO4
3. 3
   ترشيحfiltered
4. 4
   أخرىthe solvent removed under reduced pressure

الإجراء التجريبي

To a solution of 231 (25 mg, 0.06 mmol) in 4 mL of dichloromethane, acetyl chloride (8 μL, 0.12 mmol) and 4-(dimethylamino)pyridine (DMAP) (5 mg, 0.03 mmol) were added, the resulting mixture was stirred at room temperature for 15 min. Then the solution was washed with water and the organic layer was dried over Na2SO4, filtered and the solvent removed under reduced pressure to obtain 18 mg (yield 66%) of 25a as a red oil. 1H-NMR (CDCl3): 2.10 (s, 3H), 3.88 (s, 3H), 4.20 (s, 2H), 7.00-7.02 (m, 2H), 7.22-7.33 (m, 8H), 7.61-7.64 (m, 4H), 7.68 (s, 1H). MS (ESI): m/z 482 (M+H+).

المصدر